Medwave se preocupa por su privacidad y la seguridad de sus datos personales. Todos los estudios compararon bromocriptina versus cabergolina. Su principal desarrollo es la base de datos Epistemonikos www. Cabergoline and bromocriptine are among the most commonly used drugs to treat prolactinoma. Cabergoline is a long-acting dopamine receptor agonist which might offer advantages over bromocriptine.

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Cabergoline and bromocriptine are among the most commonly used drugs to treat prolactinoma. Cabergoline is a long-acting dopamine receptor agonist which might offer advantages over bromocriptine. However, it is not clear if this translates into clinical benefits. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified two systematic reviews including 12 studies addressing the question of this article, including five randomized controlled trials.

We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. It is not clear whether cabergoline is also more effective with respect to tumor growth because the certainty of the evidence is very low.

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Webster J, et al. N Engl J Med. Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas. Ono M, et al. J Clin Endocrinol Metab. Epub Mar PMID: Increased prevalence of subclinical cardiac valve fibrosis in patients with prolactinomas on long-term bromocriptine and cabergoline treatment.

Elenkova A, et al. Eur J Endocrinol. Epub Apr Is fluid restriction needed in heart failure? Show more similar articles See all similar articles. Copy Download.


Cabergoline or Bromocriptine for Prolactinoma?

The prolactinomas are the most common functioning pituitary tumors. The hyperprolactinemia is associated with anovulation and infertility. Objectives: a describe the relationship between hyperprolactinemia and fertility, b review the results of the use of dopamine agonists during pregnancy and embryo-fetal development and c review the therapeutic management in micro and macroprolactinomas during pregnancy. Cabergoline currently suggested rather than bromocriptine due to their excellent tolerability and long half-life. In general, it is recommended that fetal exposure to all drugs be limited to as short a period as possible. In the absence of menstrual period, the drug should be discontinued and confirm pregnancy. Conclusion: Both, bromocriptine and cabergoline, showed no evidence of obstetric and neonatal complications; however, experience with bromocriptine is higher.


[Update on Endocrinology: Management of Prolactinomas During Pregnancy]






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