Account Options Connexion. Afficher l'e-book. The thrust here is for those who want to know more than the answer to an exam question - an approach to disease diagnosis and treatment which emphasizes thoughtful consideration of alternatives, finding ones way through uncertainties and lack of knowledge. The annual seminar on which this volume is based has evolved into a forum for open discussion of puzzling questions - actually old questions in the light of new data.
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We'd like to understand how you use our websites in order to improve them. Register your interest. Nephropathy associated with myeloma is frequent, sometimes revealing the disease and making the prognosis worse.
Histological exam has become, thus, one of the principal keys of the diagnostic of the different lesions and so of the drawing up of the disease prognosis.
This study aimed to characterize the histological lesions of kidney during myeloma, in the Academic Hospital Center of Ibn-Rochd of Casablanca Morocco , and to indicate the immunoglobulin chains, most blamed in their occurrence. It was a retrospective study covering a period of 9 years — and collecting 18 histological reports of kidney biopsy realized in the pathologic anatomy laboratory of the academic hospital center.
The patients had a means age of The most frequent histological diagnosis of nephropathy associated with myeloma in this cohort was cast nephropathy, AL amyloidosis, and light chain deposition disease. One case of Fanconi syndrome with an aspect of proximal tubulopathy was diagnosed.
Nephropathy associated with myeloma is frequent and serious. This is a preview of subscription content, log in to check access. Pol Arch Med Wewn — Google Scholar. J Clin Invest — Leukemia — Am J Kidney Dis — Rev Med Suisse — Nephrol Dial Transplant — J Am Soc Nephrol — Blade J, Rosinol L Complications of multiple myeloma.
Hematol Oncol Clin North Am — Am J Med — Download references. Correspondence to N. Bennani-Guebessi, N. J Afr Cancer 6, — Download citation. Received : 17 September Accepted : 12 December Published : 08 January Issue Date : August Search SpringerLink Search. Abstract Nephropathy associated with myeloma is frequent, sometimes revealing the disease and making the prognosis worse.
Zamiati Authors N. Bennani-Guebessi View author publications. You can also search for this author in PubMed Google Scholar. View author publications. About this article Cite this article Bennani-Guebessi, N.
Annales de Biologie Clinique
Si continuas navegando, consideraremos que aceptas su uso. The features are hydrophthalmia, cataract, mental retardation, vitamin D-resistant rickets, amino aciduria, and reduced ammonia production by the kidney. Congenital cataracts are the basis for diagnosis. Some patients may develop bilateral glaucoma. Also, microphthalmia and enophthalmos and decreased visual acuity have been observed. In the first year of life intense hypotonia and hyporeflexia are observed, which are generally the first neurological manifestations.
Two sisters in the first year of life presented with a proximal tubulopathy of unknown etiology. They subsequently developed a pluritissular disorder including diabetes mellitus, skin abnormalities, mitochondrial myopathy with ragged-red fibers, and cerebellar ataxia. Their mother had ptosis, ophthalmoplegia, and muscle weakness. Analysis of the mitochondrial respiratory chain showed a complex III deficiency in both skeletal muscle and lymphocytes of the second girl. Southern blot analysis provided evidence for a heteroplasmic partial duplication of the mtDNA 26 kb , involving one full-length and one partly deleted mitochondrial genome and with one single abnormal junction between the genes for ATPase 6 and cytochrome b.