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The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. It is governed by the peer review system and all original papers are subject to internal assessment and external reviews.
The journal accepts submissions of articles in English and in Spanish languages. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. Read more. SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.
SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. Post-infectious acute glomerulonephritis can be manifested as a nephritic syndrome.
Macroscopic haematuria MH is self-limited and appears in more than half of cases. Kidney failure is due to inflammatory glomerular lesions. On the other hand, some patients with MH as a symptom of IgA nephropathy can undergo certain worsening of renal function due to tubular mechanisms.
We describe the case of endocapillary proliferative glomerulonephritis with haematuria and renal failure and glomerular lesions and intratubular haematic casts. A year-old female, subjected to laryngeal polypectomy 20 days before, with odynophagia and fever. Three days before being admitted, she felt general discomfort, an itchy rash, haematuria, followed by anuria. Biochemical tests showed: hypochromic anaemia, with no haemolysis data. Creatinine: 8. Normal immunoglobulins.
Normal chest ultrasound. Given that renal function rapidly deteriorated, he received steroid treatment in bolus and orally [p. The renal biopsy found: 17 glomeruli, diffuse endocapillary hypercellularity and neutrophils in capillary lumens, epithelial crescents in two glomeruli. Interstitial space with frequent haematic casts and epithelial space with denudate haematic casts Figure 1.
Immunofluorescence, mesangial deposits and in capillary walls of C 3 and IgM endocapillary proliferative glomerulonephritis. The patient progressed favourably, as shown in Figure 2, and renal function fully recovered. Our patient therefore had an acute endocapillary glomerulonephritis, possibly post-infectious, discovered with macroscopic haematuria and acute kidney failure.
For most renal biopsies, the key areas of study are the interstitial and tubular spaces, and they are analysed in detail.
However, it is necessary to seek the presence of intratubular haematic casts as the cause of tubular necrosis, which can add to massive extracapillary proliferation or vasculitis. In our case, glomerular lesions justify acute renal failure, but tubular necrosis, given the advanced stage, has possibly played a more important role. The physiopathology of the renal function disorder in MH patients is not fully understood, especially if we take into account the fact that not all haematuria episodes are associated with acute renal failure.
Iron and haemoglobin poisoning, together with tubular obstruction are the main mechanisms, 3,4 favoured by protein expression induced by intratubular-free haemoglobin, by tubular lesions, 5 and sometimes by association with interstitial nephritis. Progress is favourable by stopping macroscopic haematuria 3,6 ; however, some patients benefit from steroids if they have prolonged haematuria, are over 50 years of age, or have had previous kidney damage.
In summary, MH in cases of glomerulonephritis different to IgA can become complicated with acute failure due to tubular necrosis and intratubular haematic casts.
Its pathogenesis is not fully known and it seems that steroids may be effective in the most serious cases. Home Articles in press Archive. ISSN: Previous article Next article. September Pages DOI: Role of acute tubular necrosis with blood cast during endocapillary proliferative glomerulonephritis.
Download PDF. Olazo a , S.. Anaya a , M.. Arrambarri a , A.. Romera a , C.. Vozmediano a , I.. Ferreras a , F.. Rivera a. This item has received. Article information. To the Editor, Post-infectious acute glomerulonephritis can be manifested as a nephritic syndrome.
Acute worsening of renal function during episodes of macroscopic hematuria in IgA nephropathy. Kidney Int ; Reversible acute renal failure from gross haematuria due to glomerulonephritis: not only in IgA nephropathy and not associated with intratubular obstruction.
Nephrol Dial Transplant ; Acute renal failure in patients with glomerular diseases: a consequence of tubular cell damage caused by haematuria? Neth J Med ; August C, Atzeni A, K?? Acute renal failure in IgA nephropathy: aggravation by gross hematuria due to anticoagulant treatment.
J Nephrol ; Glomerular haematuria, renal interstitial haemorrhage and acute kidney injury. Acute kidney injury in immunoglobulin A nephropathy: potential role of macroscopic hematuria and acute tubulointerstitial injury. Ther Apher Dial ; Macroscopic hematuria in mesangial IgA nephropathy: correlation with glomerular crescents and renal dysfunction. Factors that dtermine an incomplete recovery of renal function in macrohematuria-induced acute renal failure of Ig A nephropathy.
Clin J Am Soc Nephrol ; Subscribe to our newsletter. See more. Print Send to a friend Export reference Mendeley Statistics. This work is licensed under a Creative Commons Attribution 4. Instructions for authors Submit an article Ethics in publishing. Information S. N Board Editorial Board. Article options. Are you a health professional able to prescribe or dispense drugs? Si continua navegando, consideramos que acepta su uso.
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Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Anaya and M. Arrambarri and Amparo Romera and C. Vozmediano and Isabel Ferreras and Francisco J. Rivera Published Medicine Nefrologia.
Glomerular diseases in a Hispanic population: review of a regional renal biopsy database. This study aimed to determine glomerular disease frequencies in a region of Colombia and it represents the basis for future studies. The diagnosis of each case was based on histological, immunopathological and clinical features. In cases Primary glomerular diseases were diagnosed in biopsies
Glomerulonefritis Proliferativa Extracapilar "Crescentic". Enfermedad anti-MBG - Glomerulonefritis pauciinmune. Un cuarto tipo ha sido propuesto, por algunos autores, para aquellos casos en los que se documenta coexistencia de enfermedad anti-MBG y ANCAs. Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol. Las semilunas pueden evolucionar a fibrosis semiluna fibrosa o desaparecer por apoptosis. Posteriormente fueron Lerner y cols.
The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. It is governed by the peer review system and all original papers are subject to internal assessment and external reviews. The journal accepts submissions of articles in English and in Spanish languages. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. Read more. SRJ is a prestige metric based on the idea that not all citations are the same.