Multicenter, open-label, randomized study comparing the efficacy of atorvastatin versus usual care in reducing refractory hypercholesterolemia in high-risk patients to target levels. Curr Therap Res. Status of statins, utilization and unanswered questions. Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian simvastatin survival study. Randomized clinical trials and recent patterns in the use of statins.
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Los pacientes deben consultar con su profesional de la salud si tienen cualquier pregunta o inquietud sobre estatinas. Los casos aparentemente no estaban vinculados con demencia fija o progresiva, como la enfermedad de Alzheimer.
Un estudio reciente por Culver et al. Statin-associated memory loss: analysis of 60 case reports and review of the literature. Statin-associated adverse cognitive effects: survey results from patients. Changes in memory function and neuronal activation associated with atorvastatin therapy.
Association between statin use and Alzheimer's disease. Do statins reduce risk of incident dementia and Alzheimer disease?
The Cache County Study. Arch Gen Psychiatry. Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis. Dement Geriatr Cogn Disord. Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment. J Epidemiol Community Health. Statins, risk of dementia, and cognitive function: secondary analysis of the Ginkgo Evaluation of Memory Study.
J Stroke Cerebrovasc Dis. Accessed January 31, Statins and cognitive functioning in the elderly: a population-based study. J Alzheimers Dis.
Effects of lovastatin on cognitive function and psychological well-being. Am J Med. Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults.
Pravastatin and cognitive function in the elderly. J Neurol. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Datos sobre estatinas. Evite con lovastatina: Ciclosporina Gemfibrozilo. No exceda 20 mg diarios de lovastatina con: Danazol Diltiazem Verapamilo.
No exceda 40 mg diarios de lovastatina con: Amiodarona Verapamilo. No exceda 40 mg diarios de lovastatina con: Amiodarone.
2009, Número 1
The relationship between hypercholesterolemia and the development of cardiovascular disease, especially coronary heart disease, is well established. In addition, cardiovascular disease risk is elevated in genetically inherited forms of hyperlipemia. Currently available evidence indicates that long-term lipid-lowering therapy reduces the risk of cardiovascular morbidity and mortality. Risk stratification is important for defining target LDL cholesterol levels and for selecting appropriate therapy. Statins are regarded as first-line treatment for hypercholesterolemia, and fibrates as first-line treatment for hypertriglyceridemia.
U.S. Food and Drug Administration
Statins are lipid lowering agents that promote their effects on plasma lipids through the inhibition of HMG-CoA reductase, a crucial enzyme in the cascade of cholesterol synthesis, leading to reduction of tissue cholesterol pool and consequently, to an upregulation of the LDL receptor expression. There are considerable differences among statins regarding some pharmacokinetic properties, such as the coefficient of hydrophilicity, via liver metabolism especially regarding P cytochrome and isoenzymes , plasma half-life and efficacy of serum lipid changes. They may also differ regarding interactions with other drugs that share the same pathway of metabolism. Recently, many pleiotropic effects have been reported with these drugs, such as anti-inflammatory properties, improvement in endothelial function and benefits on hemostasis. Key words: Statins, pharmacokinetics, drug interactions. Figura 5.
Hypolipidemic agents drug interactions: approach to establish and assess its clinical significance. Structured review. Franco 1,4 , Y. Henao 1 , M.