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Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia. Santiago, Chile. Correspondencia a :. Nicotinic acid increases HDL cholesterol levels, even though its specific impact on SR-BI dependent-cellular cholesterol transport remains unknown. Aim: To determine the effect of nicotinic acid on HDL particle functionality in cholesterol efflux and uptake mediated by SR-BI in cultured cells in hypoalphalipoproteinemic patients.
Conclusions: Nicotinic acid therapy increases SR-BI-dependent HDL cholesterol transport in cultured cells, establishing a new cellular mechanism by which this lipid-lowering drug appears to modulate HDL metabolism in patients with hypoalphalipoproteinemia.
Key words: Cholesterol ester transport proteins; High density lipoproteins; Niacin. Tabla 1. Figura 1. Tabla 2. Figura 2. Efecto del AN sobre los niveles de colesterol asociado a HDL2 en pacientes con hipoalfalipoproteinemia. Figura 3. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res ; Scanu AM, Edelstein C. HDL: bridging past and present with a look at the future. Komoda T editor. The HDL Handbook. Biological Functions and Clinical Implications.
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A new method for HDL particle sizing by polyacrylamide gradient gel electrophoresis using whole plasma. High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI.
The addition of niacin to statin therapy improves high-density lipoprotein cholesterol levels but not metrics of functionality. J Am Coll Cardiol ; Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. The role of niacin in lipid-lowering treatment: are we aiming too high? Curr Pharm Des ; Recibido el 15 de octubre de , aceptado el 2 de julio de Conflictos de intereses: A.
Correspondencia a: Dr. Servicios Personalizados Revista. Referencias 1.
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