JAMA ; N Engl J Med ; Intensive lipid lowering with atorvastatin in patients with stable coronary disease. Four prospective American studies.

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Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia. Santiago, Chile. Correspondencia a :. Nicotinic acid increases HDL cholesterol levels, even though its specific impact on SR-BI dependent-cellular cholesterol transport remains unknown. Aim: To determine the effect of nicotinic acid on HDL particle functionality in cholesterol efflux and uptake mediated by SR-BI in cultured cells in hypoalphalipoproteinemic patients.

Conclusions: Nicotinic acid therapy increases SR-BI-dependent HDL cholesterol transport in cultured cells, establishing a new cellular mechanism by which this lipid-lowering drug appears to modulate HDL metabolism in patients with hypoalphalipoproteinemia.

Key words: Cholesterol ester transport proteins; High density lipoproteins; Niacin. Tabla 1. Figura 1. Tabla 2. Figura 2. Efecto del AN sobre los niveles de colesterol asociado a HDL2 en pacientes con hipoalfalipoproteinemia. Figura 3. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res ; Scanu AM, Edelstein C. HDL: bridging past and present with a look at the future. Komoda T editor. The HDL Handbook. Biological Functions and Clinical Implications.

New York: Academic Press; HDL functionality. Curr Opin Lipidol ; Cardioprotective functions of HDLs. J Lipid Res ; Protective role of high density lipoproteins in sepsis: basic issues and clinical implications. Rev Chil Infectol ; Future therapeutic directions in reverse cholesterol transport. Curr Atheroscler Rep ; Hellerstein M, Turner S. Reverse cholesterol transport. Rigotti A, Krieger M.

Getting a handle on "good" cholesterol with the high-density lipoprotein receptor. N Engl J Med ; Scavenger receptor class B, type I-mediated [3H]cholesterol efflux to high and low density lipoproteins is dependent on lipoprotein binding to the receptor. J Biol Chem ; Identification of scavenger receptor SR-BI as a high density lipoprotein receptor.

Science ; The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues. Endocr Rev ; Arterioscler Thromb Vasc Biol ; Mineo C, Shaul PW. Functions of scavenger receptor class B, type I in atherosclerosis. Genetic variant of the scavenger receptor BI in humans.

Clin Genet ; McKenney J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med ; Niacin: another look at an underutilized lipid-lowering medication. Nat Rev Endocrinol ; 8: Julius U, Fischer S.

Nicotinic acid as a lipid-modifying drug-a review. Atheroscler Suppl ; Recent advances in niacin and lipid metabolism. Niacin: a long history, but a questionable future. Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism.

J Clin Invest ; Subpopulations of apolipoprotein A-I in human high-density lipoproteins. Their metabolic properties and response to drug therapy. Biochim Biophys Acta ; Effects of extended-release niacin on lipoprotein subclass distribution.

Am J Cardiol ; Niacin decreases removal of high-density lipoprotein apolipoprotrein A-I but not cholesterol ester by Hep G2 cells: implication of reverse cholesterol transport. Arterioscler Tromb Vasc Biol ; High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study.

Atherosclerosis ; High-density lipoprotein subfractions--what the clinicians need to know. Cardiology ; Clin Chim Acta ; A targeted mutation in the murine gene encoding the high density lipoprotein HDL receptor scavenger class B type I reveals its key role in HDL metabolism. Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion. Inhibition of cholesteryl ester transfer protein by Torcetrapib modestly increases macrophage cholesterol efflux to HDL.

A new method for HDL particle sizing by polyacrylamide gradient gel electrophoresis using whole plasma. High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI.

The addition of niacin to statin therapy improves high-density lipoprotein cholesterol levels but not metrics of functionality. J Am Coll Cardiol ; Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. The role of niacin in lipid-lowering treatment: are we aiming too high? Curr Pharm Des ; Recibido el 15 de octubre de , aceptado el 2 de julio de Conflictos de intereses: A.

Correspondencia a: Dr. Servicios Personalizados Revista. Referencias 1.


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