Ele foi descrito primariamente por Jacob em , que o denominou ulcus rodens , e sua nomenclatura atual foi proposta por Krompecher em Esses dados podem ser transpostos para uma estimativa anual de cerca de Na Alemanha, 96 homens e 95 mulheres;. Na Holanda, 53 homens e 38 mulheres. Os CBCs podem apresentar tamanhos variados. O subtipo pigmentado, morfologicamente, se assemelha ao anterior, apesar de haver variantes superficiais e esclerodermiformes.
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Os genes supressores de tumor atuam regulando negativamente os sinais de crescimento celular, permitindo o reparo do DNA.
Dois genes patched PTCH , localizados em 9q J Am Acad Dermatol. Tsao H. Genetics of nonmelanoma skin cancer. Arch Dermatol. Nonmelanoma cancers of the skin. N Engl J Med. Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem Photobiol. Grossman D, Leffell DJ. The molecular basis of non melanoma skin cancer: new understanding.
HLA molecules in basal cell carcinoma of the skin. Basal cell carcinoma: a dermatopathological and molecular biological update. Br J Dermatol. UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement. Proc Natl Acad Sci. Frequent clones of pmutated keratinocytes in normal human skin. Persistent p53 mutations in single cells from normal human skin. Am J Pathol. Carcinoma Espinocelular.
Rio de Janeiro: Medsi; Beiguelman B. Rio de Janeiro: Guanabara-Koogan; Lewin B. Genes VIII. The sequence of the human genome. The clinical importance and prognostic implications of microsatellite instability in sporadic cancer. Eur J Surg Oncol. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Melanoma Res. Human malignant melanoma. A genetic disease? Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels.
J Cutan Pathol. Loss of one HuD allele on chromosome 1p selects for amplification of the N-myc proto-oncogene in human neuroblastoma cells.
Beroud C, Soussi T. APC gene: database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res. BRCA1 gene in breast cancer. J Cell Physiol. The role of the breast cancer susceptibility gene 1 BRCA1 in sporadic epithelial ovarian cancer. Reprod Biol Endocrinol. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Human homolog of patched, a candidate for the basal cell nevus syndrome. Knudson AG.
Mutation and cancer: statistical study of retinoblastoma. Malkin D. Germline p53 mutations and heritable cancer. Annual Rev Genet. Mutation in the p53 tumor supressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. Levine AJ. Tumor suppressor genes in breast cancer: the gatekeepers and the care takers. Am J Clin Pathol. Molecular aetiology and pathogenesis of basal cell carcinoma. J Dermatol Sci.
Value of p53 protein in biological behavior of basal cell carcinoma and in normal epithelia adjacent to carcinomas. Pathol Oncol Res. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.
J Invest Dermatol. Giglia-Mari G, Sarasin A. TP53 mutations in human skin cancers. Hum Mutat. Sunburn and p53 in the onset of skin cancer.
Tornaletti S, Pfeifer GP. Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer. Boukamp P. Non-melanoma skin cancer: what drives tumor development and progression? Squamous cell carcinoma of the skin excluding lip and oral mucosa. P53 mutations in nonmelanoma skin cancer of the head and neck: molecular evidence for field cancerization. Genetic change in actinic keratoses. Basal cell carcinomas and squamous cell carcinomas of human skin show distinct patterns of chromosome loss.
Clonal chromosome abnormalities in premalignant lesions of the skin. Cancer Genet Cytogenet. Sherr CJ. Principles of tumor suppression.
UV-B-type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas. Int J Cancer. Delineation of two distinct deleted regions on chromosome 9 in human nonmelanoma skin cancers. Genes Chromosomes Cancer.
Hodges A, Smoller BR. Immunohistochemical comparison of p16 expression in actinic keratoses and squamous cell carcinomas of the skin. Mod Pathol. P16INK4a expression in actinic keratosis and Bowen's disease. Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16ink4a tumor suppressor. Cancer Lett. Molecular and cellular biology of basal cell carcinoma.
Australas J Dermatol. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet. Kalderon D. The mechanism of hedgehog signal transduction. Biochem Soc Trans. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI Clin Exp Pharmacol Physiol.
Rio de Janeiro: Guanabara Koogan; Some microsatellites may act as novel polymorphic cis-regulatory elements through transcription factor binding.
Vida después del tratamiento de cáncer de piel de células basales o de células escamosas
Background: Skin cancer is the most frequent cancer related to ultraviolet radiation. The aim was to estimate the incidence of skin cancer type, melanoma and non-melanoma in Zacatecas, Mexico. Methods: An epidemiological study was carried out during the period from to The incidence and the global prevalence were estimated.
2015, Número 2
Cancer Treat Rev ; Systematic skin cancer screening in Northern Germany. J Am Acad Dermatol ; Tumores malignos.
[Skin Cancer Incidence in Zacatecas]
There is no unanimous consensus for all tumor cases, based on the histological type, size, depth, and location of the lesion. The objective is to analyzed the approach used in skin neoplasias in the head and neck, focusing on the treatments performed, recurrence, and follow-up. During 36 months of follow-up, the efficacy of the chosen treatment, recurrence, side effects, complications, and esthetic satisfaction of patients were observed. Statistical analysis was performed using the Fisher's exact test.
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