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Chemical compatibility of piracetam determined by differential scanning calorimetry. La Habana, Cuba. La figura 2 muestra los termogramas de las mezclas formadas entre IFA y excipientes. ABSTRACT Introduction: the first phase of the drug preformulation comprises the selection of excipients and the conduction of studies on chemical compatibility between pharmacologically active ingredient and the excipients.
One of the quickest techniques is the differential scanning calorimetry and the supplementary technique called thermogravimetic analysis. Objective: to conduct a chemical compatibility study of the pharmacologically active ingredient and of the preselected excipients by using differential scanning calorimentry DSC and thermogravimetric analysis TG , in order to confirm the chemical interaction between them. The pharmacologically active ingredient was Piracetam and the excipients were Aerosil Kollidon VA64, magnesium stearate, microcrystalline cellulose, Polyethylene glycol 20 The differential scanning calorimetry characterized the excipients and the pharmacologically active ingredient as well, whose physical fusion transition was determined.
Some binary physical mixtures with a concentration ratio of were prepared to study compatibility. Two endothermal transitions were determined as well as the fusion transition by the TG equipment. Figure 2 showed the thermograms of mixtures between pharmacologically active ingredient and excipients. Conclusions: the occurrence of new peaks was bit detected, so it was inferred from this study that there was no chemical incompatibility between the studied substances, and the excipients are recommended for the development of the final pharmaceutical formulation.
Key words: differential scanning calorimetry, incompatibility chemistry, physical mixtures binary, Piracetam. Servicios Personalizados Revista. Citado por SciELO. Similares en SciELO. Ford J. John Wiley Sons, Ed. New York, Acta Pharm. Jugosl, ; Sweetman SC. London Recibido: 5 de julio de Aprobad: 3 de septiembre de CP 10
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